- Cystocele repair failure symptoms. Nov 8, 2022 · Symptoms of a Prolapsed Bladder The first symptom that women with a prolapsed bladder usually notice is the presence of tissue in the vagina that many women describe as something that feels like a A cystocele usually does not cause serious health problems. Oct 11, 2022 · Bladder prolapse, also known as pelvic organ prolapse or cystocele, is a condition that affects people with a vagina. A cystocele is a type of pelvic organ prolapse. Telling your healthcare provider about your symptoms helps them locate the spots where your pelvic floor is weakest. These symptoms typically resolve in a couple weeks once the tissues have healed. Treatments range from watchful waiting to surgery. scrotal cystocele Jul 2, 2024 · The earliest stages of bladder prolapse often do not cause symptoms. What are symptoms of pelvic organ prolapse? Some of the most common symptoms of pelvic organ prolapse are: Seeing a bulge or lump coming from your vagina. Simply defined, a cystocele is a protrusion of the bladder into the vagina due to defects in pelvic support (Fig. This is medication to make you sleep. When you discuss bladder prolapse with your doctor, they may call it by another name: cystocele. May 1, 2008 · Pelvic prolapse can recur in up to 50% of patients who undergo anterior colporrhaphy. Rectum: The last part of the digestive tract. Unlike many other reconstructive surgeries used to treat pelvic organ prolapse (POP), your provider can perform the procedure without having to make a large incision (cut) into your abdomen. A small posterior vaginal prolapse (rectocele) might cause no symptoms. It is When none or just one of these symptoms was present, outcome of rectocele repair was considered successful. There are three stages, or grades, of bladder prolapse. The treatment of cystocele may vary depending on various factors such as the severity of the disease and the presence of symptoms or any underlying medical conditions. Apr 6, 2023 · Mild cases — those with few or no obvious symptoms — typically don't require treatment. pelvic-floor exercises; placing a pessary; vaginal estrogen cream; Alternatively, you can choose to have no treatment and monitor your symptoms. Many people with prolapse also are in menopause. Not doing certain activities, such as heavy lifting or straining during bowel movements, that could cause the cystocele to get worse. Usually, there is a partial failure in these cases and requires no treatment or sometimes pessary (device placement in the vagina) or less extensive surgery than originally may help. Antibiotic are given during surgery and continued after your operation to reduce the risk of infection. Learn about the symptoms, causes, diagnosis and treatment options for this condition, including surgery and pessary devices. Oct 17, 2022 · A cystocele, otherwise known as a protrusion of the bladder, occurs when the bladder descends into the vagina. While most people who undergo the procedure experience improvement in their symptoms, prolapse can reoccur, requiring While it is common to have some degree of bladder and urethral prolapse, few people ever have any symptoms. Losing weight may reduce symptoms. Dr. Cystocele Treatment for Cystocele Treatment for a cystocele includes cystocele repair surgery, surgery to place a urethral sling, or both. Treatment for anterior prolapse depends on the grade of the cystocele. Surgical mesh was used in about one out of three procedures. A prolapsed bladder is commonly associated with prolapses of other organs within a woman's pelvis. The other option is more invasive and consists of a surgical repair of the cystocele. g. Patients may be asymptomatic or could describe vaginal pressure or bladder symptoms. In this surgical procedure, the doctor will make an incision into the back wall of the vagina. 70 to 3. Not being able to control bowel movements. Aug 10, 2022 · Symptoms. underwent surgery to repair SUI in 2010, with mesh placement being used in over 80% of the procedures. Pelvic organ prolapse (POP) refers to the protrusion of one or more female pelvic organs outside the pelvis through the vagina including uterus, bladder and intestines, and causes the pelvic organs to drop downward to the vaginal wall. As an alternative, cystocele repair with non-frozen cadaveric fascia lata allows for correction of both central and lateral cystocele defects with durable long-term results. Some may need another repair surgery to correct the problem. Shaw is able to replicate the same procedure that is done with a large (open) incision with the latest technology. . 29, 95% confidence Interval (CI) 1. Ellington , MD, Donna Mazloomdoost , MD, Ryan Whitworth , MPH, Marie G. This is called a cystocele. Vaginal Vault Suspension – Most commonly a laparoscopic procedure to repair the vaginal wall Oct 17, 2022 · Cystocele management requires careful consideration of several factors such as a women's age, physical & sexual activity, future reproductive wishes, the nature and extent of the symptoms, the degree of the prolapse, associated uterine, or posterior wall prolapse, and incontinence symptoms. Chronic constipation : Bearing down or straining too hard to poop can weaken your pelvic muscles over time. These have been shown to have lower failure rates, but many factors go into proper use of these materials in patients, and come with their own inherent risks. Mar 2, 2022 · In surgical repair of pelvic organ prolapse the recurrence rate is about 30% and the importance of apical support was recently highlighted. Once the fascia is detached from the tendinous arch, a paravaginal fascial repair is added 3. Bladder spasms (cramping). Rectocele Repair Symptoms of a cystocele include feeling pelvic pressure, a vaginal bulge, trouble emptying the bladder, or frequent urinary tract infections. Medications. When there is a weakness in the front wall of the vagina, the bladder can prolapse into the vagina. The surgery attaches the vaginal vault to the sacrum with surgical mesh. Weight loss. 1 In the UK, POP accounts for 20% of women waiting for major gynecological surgery and is a leading indication for hysterectomy in postmenopausal Native tissue anterior compartment prolapse repair remains an important surgical procedure for pelvic prolapse. Fragmin or Clexane) to thin your blood is given during surgery and… Continue Reading» Risk Factors for Surgical Failure and Worsening Pelvic Floor Symptoms Within 5 Years After Vaginal Prolapse Repair Sharon Jakus-Waldman , MD, MPH, Linda Brubaker , MD, MS, John Eric Jelovsek , MD, MMEd, Joseph I. The prolapse might not be the cause of urinary and bowel symptoms, although they can be linked. This is done vaginally, using sutures to support the muscles and tissue that hold the bladder in place. Symptoms of vaginal prolapse include the feeling of vaginal pressure or fullness — like you’re sitting on a small ball — and the sensation that something has fallen out of your vagina. In some cases, a bulge of tissue in your vagina that you can see or feel. Bekken met een cystocele (gevallen blaas) Een cystocele ook bekend als een verzakte, hernia, gevallen of gevallen blaas (waar uw urine of “water” wordt opgeslagen) ― treedt op wanneer ligamenten die uw blaas omhoog houden en de spier tussen de vagina en de blaas van een vrouw uitrekken of verzwakken, waardoor de blaas in de vagina zakken. Dec 12, 2022 · Learn about cystocele, a condition when your bladder shifts and pushes on the outside wall of your vagina, and how it's treated with surgery. S. The most common symptoms post rectocele surgery is slight pelvic and rectal discomfort and pressure, as well as slight vaginal bleeding, and minimal pain during bowel movements. If you have a cystocele with symptoms, your health care professional may recommend nonsurgical treatment or surgery, depending on the severity of the cystocele, your age, other health problems, sexual activity, desire for future children, and personal preferences. Nov 24, 2023 · Purpose Obstructed defecation syndrome represents 50–60% of patients with symptoms of constipation. Rectocele Repair – A rectocele repairs the fallen rectum and small bowel (enterocele). 1). Post operation there are a few things that may occur. Jul 31, 2017 · Anterior vaginal repair was less effective than open abdominal retropubic suspension based on patient‐reported cure rates in eight trials both in the medium term (failure rate within one to five years after anterior repair 97/259 (38%) versus 57/327 (17%); RR 2. If your symptoms go on, you may want to talk to your doctor about surgery. Cystocele, or bladder prolapse, is a condition in which the bladder sags down into the vagina due to the weakening of the supporting structure between the bladder and the vagina. In addition, if a patient felt a bothersome bulge or sensation of prolapse, another surgery was necessary, or a removable pessary was necessary to relive her symptoms, the procedure also was considered a failure. Some women with cystocele problems remain active and largely symptom free while others require prolapse surgery for debilitating symptoms. Furthermore, all patients were asked to score the outcome of their operations as excellent, good, moderate, or poor. Pelvic organ prolapse (POP) is subcategorized according to the compartment of descent. IC is a painful bladder condition that affects millions of Americans, more often women than men. Sexual problems. Your surgery will take 1 to 2 hours. Schaffer , MD, David R. If those symptoms are not linked to the prolapse, then treatment for the prolapse might not improve them. Why do you need to repair a rectocele? Healthcare providers usually only recommend surgical repair for rectocele if you have bothersome symptoms — like vaginal bulge, difficulty pooping, pain or sexual dysfunction — and nonsurgical treatments don’t help. Dec 12, 2022 · Treatment for Cystocele Treatment for a cystocele includes cystocele repair surgery, surgery to place a urethral sling, or both. Talk to your doctor about steps you can take to reduce symptoms. Cystocele repair is a surgery to lift and tighten the prolapsed bladder tissue. Urethral About 300,000 women in the United States underwent surgery to repair POP in 2010. Thus, timely medical care is recommended to evaluate for and to prevent problematic symptoms and complications caused by weakening tissue and muscle in the vagina. Sometimes there are minimal to no symptoms and you just see an unsightly mass. Depending on the side of the defect, the repair can either be anterior, posterior, vault or total. AskApollo online Health Information Library is an initiative by Apollo Hospitals for general people, patients, their families and friends who seek useful health information, tips and advice on disease, procedure and certain medications to help you take care of yourself and your loved ones. Surgery is not required unless your Women typically recover from the cystocele repair in about 4-6 weeks. Your surgeon will fix the wall between your bladder and vagina to keep your bladder from moving again. However, follow-up visits are needed to monitor the progression of the prolapse. Cystocele Repair Introduction. Apr 11, 2016 · The gold standard for rectocele repair is still a matter of debate. Gantz , PhD, and NICHD Pelvic Floor Apr 26, 2024 · If symptoms get worse and affect your quality of life, you might need surgery. Or the symptoms do not appear for years. Posterior repair: correction of bowel prolapse (rectum bulges forward into the vagina; rectocele) Vault repair: treat prolapse of upper vagina. e. Apr 12, 2021 · Symptomatic patients may experience fullness or pressure in the pelvis or vagina, a "ball" or "lump" protruding from the vagina, lower back pain or pressure, problems with bladder emptying or Feb 10, 2006 · I just discovered another bladder prolapse after having surgery 4 months ago!! I'm quite upset and a bit disheartened. The symptoms of a cystocele withdraw after its repair; however, some symptoms, such as stress incontinence, may require a separate surgery to recede. [13] Rectocele repair is also sometimes called posterior colporrhaphy. Your doctor may recommend rectocele repair if other treatment methods have not improved your symptoms. Feb 21, 2022 · Overzicht Wat is een cystocele? Normaal bekken. May 3, 2023 · A cystocele is a type of pelvic organ prolapse that allows your bladder to sag into your vagina. Surgery is not required unless your Mar 21, 2024 · Bladder sling complications sometimes resemble symptoms of interstitial cystitis. Newer treatment of cystocele and rectocele involves minimally invasive surgery. But as the condition obstructive pulmonary disease, urinary incontinence may be necessary to repair the cystocele. There are three grades of cystocele: Grade 1: The mildest grade of cystocele, characterized by the bladder dropping only a little into the vagina ; Grade 2: More moderate grade characterized by the bladder having dropped far enough into the vagina to reach the vaginal opening While it is common to have some degree of bladder and urethral prolapse, few people ever have any symptoms. Rectocele: Your rectum bulges into your vagina. Everything else seems good, I had a hysterectomy, rectocele repair, suburethral sling placed, and a perineoplasty all at once. Bladder training. You may find relief by making lifestyle changes and doing exercises to make the pelvic muscles stronger. Common symptoms of IC that may also be symptoms of bladder sling complications include pelvic and bladder pain, painful sexual intercourse and urinary urgency. Pain or aches when you do something active. If symptoms are bothersome, treatment may include pelvic floor exercises, a pessary, and, if symptoms are severe, surgery. Sacrohysteropexy: A type of surgery to repair uterine Failure rate: None of these procedures has a 100% successful rate. Reconstructive Surgery: Surgery to repair or restore a part of the body that is injured or damaged. This procedure can also be combined with related operations like a hysterectomy or repair of uterine prolapse. The repair is achieved by the placement of permanent mesh that may result in a stronger repair. Risks. what the chances of a reoccurence was and she said it wouldn't happen. In surgical randomized controlled studies, the external validity can be compromised because the surgical outcomes often depend on surgical volume. When you lie down, they may ease. [1] The bladder bulges through the anterior wall of the vagina, with which it is anatomically associated. Depending upon the severity of your cystocele and other factors, including age and health, your urologist will recommend an individualized treatment plan which may include: Activity modification to avoid heavy lifting or straining that could worsen your cystocele. Are there any alternatives to an anterior repair? If you have only a mild prolapse, your doctor will usually recommend that you have an anterior repair only after you have tried simple treatments. Rectocele Repair Dec 31, 2018 · Introduction. Cystocele Estrogen supplementation may also be added. Schedule an appointment by calling (888) 264-1533. Your bladder may feel full all the time. The controversy concerning the anatomic importance of the rectovaginal septum and the extension of Denonvilliers’ fascia, the lack of correlation between the reported symptoms and the size of the rectocele, the role of associated pelvic floor abnormalities, and the small number of patients operated on in many specialist May 18, 2023 · Bladder prolapse (cystocele), or a dropped bladder, is one type of pelvic organ prolapse. I’m 12 weeks post op, and I’m pretty certain my cystocele repair failed. The most commonly found defect is in the anterior compartment with the finding of a cystocele on exam. Methods PubMed/MEDLINE, ScienceDirect, Cochrane Library, and Web of Science databases were searched using the terms pelvic floor, cystocele, anatomy, connective tissue, endopelvic fascia, and pelvic mobility. urinary bladder hernia. The goal of rectocele repair is to strengthen the wall between the vagina and rectum. Treatment can help if you have symptoms that limit what you can do. Urinary symptoms were relieved in 44 Jan 5, 2024 · A cystocele alone can be treated with a retropubic (Burch) colposuspension, which comprises the suspension of the lateral aspects of the bladder from the pelvic sidewalls. A cystocele occurs when the muscles and supportive tissues between a woman’s bladder and vagina weaken and stretch, letting the bladder sag from its normal position and bulge into the vagina or through the vaginal opening. Signs and symptoms can include the feeling that something has dropped out of your vagina, leaking urine or a feeling of incomplete emptying of your bladder. lateral defect of the cystocele or apical failure was May 22, 2013 · In nearly one-third of cases%2C surgical repair failed or women saw symptoms return; About 225%2C000 women undergo some kind of pelvic organ prolapse surgery each year Sep 30, 2012 · Cystocele repair has been a challenge to pelvic floor surgeons. Stress incontinence, urge incontinence and fecal incontinence often coexist with POP because they share similar risk factors. We retrieved 612 articles, of which 61 matched May 29, 2018 · Anatomical failure was a cystocele ≥ grade 2. I asked the Dr. You may feel pressure in your vagina. If women do not have symptoms or symptoms are mild, no treatment is needed. Otherwise, you may notice: A soft bulge of tissue in the vagina that might come through the opening of the vagina; Trouble having a bowel movement; Feeling pressure or fullness in the rectum; A feeling that the rectum has not completely emptied after a bowel movement Developing an enduring repair is the “holy grail” of pelvic floor surgery, and many things have been introduced, such as tissue or mesh grafts, to strengthen these surgeries. Functional cure was assessed by symptomatic improvement and questionnaires. Differential diagnosis. Aug 4, 2024 · A collagen disease, such as Marfan syndrome; What are the signs and symptoms of a cystocele? A soft bulge or lump in your vagina; Low back pain that is relieved when you lie down; Pelvic pain or pressure, especially when you urinate or have sex; Pink or red urine; Pressure in your abdomen, or you feel that you cannot completely empty your bladder While it is common to have some degree of bladder and urethral prolapse, few people ever have any symptoms. Behavior therapies such as Kegel exercises to strengthen the pelvic floor. Jul 27, 2020 · Post-Op Rectocele Repair. When symptoms do appear, they may include difficulty urinating, uncontrolled release of urine (urinary incontinence), and pain during sexual intercourse. ) the management of the urinary incontinence differed after cystocele repair. Sep 4, 2015 · Introduction and hypothesis We updated anatomic theories of pelvic organ support to determine pathophysiology in various forms of cystocele. Suburethral tape was inserted in the same operative time at the end of the cystocele repair procedure, through a distinct vaginal incision, to avoid the risk of its displacement. , avoiding heavy lifting or straining that could cause the cystocele to worsen) Symptoms of a cystocele include feeling pelvic pressure, a vaginal bulge, trouble emptying the bladder, or frequent urinary tract infections. Most people do not have problems after repair surgery. Jul 1, 1998 · Diagnosing and Treating a Cystocele . In order to restore the normal anatomy, the bladder can be lifted by simply tightening the muscles underneath (anterior colporrhaphy), or by using a special netting called mesh. Doctors start by closely monitoring the woman and her symptoms. Sacrocolpopexy: A type of surgery to repair vaginal vault prolapse. If you do have symptoms of anterior prolapse, first line treatment options include: Apr 6, 2023 · When signs and symptoms occur, they may include: A feeling of fullness or pressure in your pelvis and vagina. Feeling pressure in your pelvis. Your cystocele usually does not need treatment if you don’t have symptoms. These symptoms include: A feeling of pressure or fullness in the pelvis and vagina A bulge of tissue in the vagina that is visible Increase in pelvic pressure when coughing, straining, or lifting Difficulty urinating or starting a stream of urine A cystocele, also called a prolapsed or dropped bladder, is the bulging or dropping of the bladder into the vagina. Your provider may recommend a wait-and-see approach, with occasional visits to monitor your prolapse. Mar 3, 2023 · Bladder prolapse can cause several symptoms, including a vaginal bulge, urinary incontinence, frequent voiding of the bladder, and more. Mild cases of vaginal prolapse do not require treatment. I haven't called her, yet. Any woman who notices symptoms of a prolapsed bladder should contact her doctor. The majority of ureteral injuries here are during vaginal vault reconstruction or vaginal cuff closure, where sutures can ligate (be tied to) the ureter or kink the ureter by displacing it. Laparoscopic surgery can provide a method for reconstruction of the pelvic floor and its contents without the need for a large abdominal incision. This procedure is used to repair sinking or bulging of the anterior vaginal wall. What is da Vinci Robotic Surgery? The average age of my repair patients is 54. Cystocele repair (also called Anterior Repair or Anterior Colporrhaphy) is the surgical elimination of the bulge and restoring normal anatomy. There are multiple underlying causes for the development of cystocele resulting in weakness of the muscles and the connective tissue surrounding the bladder and vagina. These include adverse reactions to the anaesthetic, excessive bleeding, infection and the potential for blood clots. Sep 30, 2012 · Cystocele repair has been a challenge to pelvic floor surgeons. See also. Rectocele Repair. Colporrhaphy is a surgery used to repair weaknesses in your vaginal walls that are causing unpleasant symptoms. 08) and in the long term (after five Aug 22, 2022 · Your symptoms depend on where your prolapse is located. Native tissue cystocele repair has been performed safely since the advent to modern vaginal surgery for prolapse. Methods This study is a retrospective review of 131 female patients who were diagnosed with Sling placement at the time of cystocele repair allows simultaneous treatment of symptomatic SUI, as well as occult SUI demonstrated preoperatively with cystocele reduction, with minimal risk of urinary retention. Shaw is proud to offer da Vinci laparoscopic, robotic and vaginal repair of pelvic prolapse issues. Urethral Cystocele Repair – This surgery repairs a prolapsed bladder or urethra (urethrocele) Hysterectomy – This is a complete removal of the uterus. Difficulty emptying the bladder that necessitates the use of prolonged catheter use or self catheterisation in less than 1% of patients; Blood loss requiring transfusion < 1% There are general risks involved with having any surgery. Apr 21, 2023 · A rectocele repair procedure can help with symptoms of pelvic organ prolapse. We aimed to compare the two frequently performed surgical methods, laparoscopic ventral mesh rectopexy and transperineal mesh repair, for this condition in terms of functional and surgical outcomes. Native tissue repair has been well-studied and is successful in relieving vaginal bulge symptoms and reducing prolapse within the vagina. Repair of high-grade pelvic prolapse (that is, grade 4 cystocele [hernia of the bladder] or total uterine prolapse) pose a particular risk for ureteral injury. Symptoms include: While it is common to have some degree of bladder and urethral prolapse, few people ever have any symptoms. Cystocele repair (bladder prolapse repair) is one of the most commonly performed types of prolapse surgery. The supportive tissues that normally hold up the bladder become weak, and the bladder can drop or fall inside the pelvis. You may be able to feel or see a bulging at the opening of the vagina. Failure to correct cystocele or stress incontinence in 10%; Urinary urgency or urge incontinence in 5%; Urinary tract infections and wound infections in 2-5% of patients. Cystocele repair was combined with rectal prolapse repair in 10% of prolapse surgeries, with hysterectomy (surgical removal of the uterus) in 6%, and with both procedures in 16%. They may resume their daily activities, including sexual intercourse, in about 4 weeks after the procedure. Cystocele characterizes anterior wall herniation, rectocele refers to the posterior vaginal wall descent, and vaginal vault prolapse characterizes the descent of the uterus, cervix, or apex of the Oct 10, 2023 · The symptoms might be strongest if you have to stand for a while. Apr 5, 2021 · ABOUT US. The symptoms of a cystocele may include: a vaginal bulge; Since the failure rate in cystocele repair remains high, additional surgery may be needed. Jan 31, 2013 · I had hysterectomy, cystocele, rectocele repair 7 months ago, and I just noticed my bladder prolapse is back! I was in shock! I followed my doctor's post-op orders: no lifting, pushing, pulling etc, but got back to doing my regular activities at 3-4 mos post op. Extent of the disease; Your tolerance for specific medications, procedures, or therapies; Expectations for the course of the disease; Your opinion or preference; Treatment may include: Activity modification (i. It happens when the wall between your bladder and vagina weakens. Because of the known high failure rate of conventional methods, use of a graft or mesh as a reinforcing material has been popularized, but specific complications related to these procedures have begun to be clarified. Dec 6, 2022 · Pelvic organ prolapse can lead to symptoms that bother you, such as: Leaking urine by accident. Symptoms of anterior vaginal wall prolapse include: You may not be able to empty your bladder completely. Cystocele repair surgery A cystocele repair is a surgery to put your bladder back in its normal place. SYMPTOMS There are several common symptoms that are present in most cases of bladder prolapse. How is a cystocele treated? Treatment depends on the grade of the cystocele and may include: Activity changes. Apr 24, 2018 · A procedure was considered a failure if, after 5 years, the repaired tissue descended past the upper third of the vaginal canal. Learn about the recovery time, possible complications, and when to avoid or seek this procedure. A cystocele or rectocele usually occurs with vaginal prolapse. After your surgery, you may have: Infection. Pelvic organ prolapse can result in symptoms including urinary leakage, constipation, and difficulty with intercourse. About 250,000 women in the U. A 2002 study indicated cystocele repair accounts for 8% of all prolapse repair surgeries; in 1997, approximately 18,500 cystocele repairs were performed. Oct 3, 2022 · Pelvic organ prolapse is the descent of pelvic structures into the vagina due to ligament or muscular weakness. Increased pelvic pressure when you strain, cough, bear down or lift. Mar 19, 2020 · The prevalence of POP reaches 3–6% as measured by symptoms and up to that repair of a lateral defect of the cystocele is crucial. Surgery is not required unless your Jul 19, 2023 · Pelvic organ prolapse increases in risk with parity and as women age. Mar 22, 2022 · Chronic cough or bronchitis: Prolonged coughing associated with asthma, smoking and respiratory disease can also strain your pelvic floor over time, making you more susceptible to rectocele. Call Now : (888) 268-1108 Oct 12, 2022 · Cystocele: Your bladder bulges into your vagina. Nov 9, 2023 · Pelvic organ prolapse increases in risk with parity and as women age. Factors that increase your risk of a cystocele are childbirth, age, obesity, chronic constipation and heavy lifting. Find out the risks, recovery, and follow-up of cystocele repair and sling procedures. Jun 1, 2022 · You will need general anesthesia for repair surgery. According to studies, 5-15% of women may have to face failure even after a prolapse repair surgery. Medication (e. Results of prolapse repair have been excellent and durable, with a symptomatic cure rate of 94% at long-term follow-up. Women may describe a dragging sensation or pressure in the vagina. Some can feel a lump protruding out of the vagina. Enterocele: Your small intestine bulges against your vaginal wall. Reoperation rates are low and Learn more about the female urology condition cystocele and how UC Irvine Medical Center's Department of Urology treats this urological disorder. Vaginal bleeding. The outcome was considered as a failure when two or more of these symptoms were recorded. Surgery is not required unless your Nov 11, 2014 · For all other cases (mixed urinary incontinence, bladder hypocontractility, etc. nioek dlof pzjug lutzx ckyccz jzgq cdrug mtcn fkgkpn ukh